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If the detoxification processes arent working correctly, they can easily cause the detoxification circuit to become toxic

Please note : This article was updated in May 2022 to correct source material and factual inaccuracies

Neurosci Letters

Therefore, the upregulation of ZEB1 during EMT enhances the sensitivity of tumor cells to ferroptosis ( 4.1.3 Hypoxic conditions promote ferroptosis The hypoxic state in the tumor microenvironment can also increase the sensitivity of tumor cells to ferroptosis