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Description

Yang, Marina Pasca di Magliano, Costas A

PROTACs are emerging as an excellent class of small molecule therapies for cancer and other diseases

Histone deacetylase (HDAC) inhibitorssuch as vorinostat and valproic acidhave been shown to induce CSC differentiation and impair tumor-initiating capacity in preclinical models

Data availability All clinical safety and efficacy data have been detailed for each patient and can be found in the extended online data document and on the Nature Medicine website