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SKU: 67045531684
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All animals were placed in groups in conventional cages at 2122 C, 3070% humidity, and a 12 h light/12 h dark cycle

Gastroenterology 2009;136:107080

29 Moreover, cathepsin S generated by tumour cells and macrophages mediates BBB transmigration through proteolytic processing of the junctional adhesion molecule, JAM-B, providing a rationale for the use of the cathepsin S-specific inhibitor VBY-999 in reducing experimental brain metastasis