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193,194 Fetuin-A inhibits glucose-stimulated insulin secretion and, in conjunction with non-esterified fatty acids (NEFAs), activates Toll-like receptor 4-mediated proinflammatory pathways in adipocytes and macrophages

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Mutations in the MFN2 gene coding for mitofusin 2 have been found to cause MSL with Charcot Marie Tooth Disease (268)

During inflammatory processes, cells generate large amounts of ROS and reactive nitrogen species, which not only directly harm tissues but also activate inflammatory signaling pathways, enhancing the sensitivity of pain receptors and intensifying pain perception