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For instance, the cysteine protease legumain can cleave TrkB, potentially generating soluble receptors that act as BDNF scavengers, thereby attenuating signalinga mechanism that may be relevant in neurodegeneration (Holzner et al., 2023)

30 , 335350.e4 (2020)

Second, the execution core of ferroptosis involves the peroxidation of polyunsaturated fatty acid-containing phospholipids(PUFA-PLs) in membrane lipids, leading to the massive accumulation of cytotoxic lipid peroxidation derivatives such as specific lipid hydroperoxides and reactive aldehydes like 4-hydroxynonenal(4-HNE), ultimately causing irreversible damage to plasma membrane integrity (Guo et al., 2024)