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In one of our previous studies [80], we found that the levels of NNMT expression in extensor digitorum longus muscles (a typical type of fast-twitch muscle relying on anaerobic metabolism to produce power) are higher than those in the soleus muscle (a typical type of slow-twitch muscle relying on aerobic metabolism to produce power) and that anaerobic exercise is more effective in increasing NNMT expression in skeletal muscles compared to aerobic exercise

Phase 2 trial (Lancet 2021) tested cagrilintide 0.3 mg through 4.5 mg/week as monotherapy and reported a clear dose-response, with 10.8% mean weight loss at 4.5 mg/week at 26 weeks

Cagrilintide is a new type of weight loss drug known as an amylin analogue

Result: By redistributing mechanical forces, NMT minimizes pain caused by nerve compression and relieves pressure on muscles and tendons