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156 Besides, with the consumption of extracellular glutamine, GDH can also catalyze ammonia derived from glutaminolysis and -KG to support the synthesis of glutamate and downstream metabolites by reductive amination in a NADPH consumption manner to meet the cancer cells growth

However, uncontrollable release in other macrophage phenotypes or cells causes dose-dependent toxicity, which attributes to nonspecifically chelate physiologically essential iron

Based on these findings, the FDA granted accelerated approval in 2024 to this combination therapy for KRAS G12C mutated CRC

Ferroptosis is closely associated with various liver disorders, including drug-induced liver injury, liver fibrosis, alcoholic liver injury, nonalcoholic fatty liver disease, hepatic ischemia-reperfusion injury, and liver cancer 44,45