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It is primarily manifested by increased intracellular iron levels and enhanced lipid peroxidation, ultimately leading to cell death characterized by mitochondrial shrinkage, loss of cristae, and disruption of membrane integrity ( The Gut Microbiota, as a vital component of the intestinal microenvironment, plays a pivotal role in maintaining intestinal homeostasis, modulating host immune responses, participating in metabolic regulation, and promoting nutrient absorption

The mucin-degrading enzymes secreted by these bacteria disrupt the mucus layers structure, leading to heightened intestinal mucosal permeability (102)

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Because ascorbic acid is present as the monoanion at near-neutral pH, it is the key species in the biochemistry and subsequent biology of vitamin C