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Unsaturated aldehyde, 4-hydroxynonenal (HNE) alters the structural integrity of HSA with consequences in the immuno-pathology of rheumatoid arthritis

Most small molecule binders of the oxytocinase subfamily of M1 aminopeptidases, e.g., the phosphinic pseudotripeptides 4346 address the active site and establish strong interactions with the catalytic zinc ion

While gene therapy is available for a small subset of patients with specific mutations, developing a therapeutic that broadly targets the cellular stresses that lead to cell death could address a major unmet need

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