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Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration

It is intriguing to see that cellular metabolism and immune activation are so tightly entangled and that a fine-grained interplay is essential to achieve a correct function, said Karsten Hiller, Ph.D., a co-author of the current study and a professor at the Braunschweig University of Technology

In particular, the activated immune cells can release various pro-inflammatory cytokines, binding with receptors expressed in neurons and glial cells, and then spread to the brain via the blood-brain-barrier and can result in the neuroinflammation and death of neurons in the brain (Dantzer et al., via the activation of the TLR4 (Alhasson et al., Amino acids and gut microbiota-brain axis in PD Source and composition of amino acid in dietary proteins In the gastrointestinal tract, enterocyte peptidases further hydrolyze resultant peptide products into amino acids, dipeptides, and tripeptides for enterocyte transport into the portal venous system