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conducted liquid chromatography-tandem mass spectrometry (LC-MS) to follow a 12-year longitudinal follow-up of 2,422 normoglycemic individuals from the Framingham Offspring cohort ( Lac-Phe, an exercise-induced circulating metabolite first characterized by Li et al., has been identified as a potent signaling molecule that effectively suppresses food intake and promotes weight reduction in diet-induced obese mice ( 5 Pathophysiological effects of phenylalanine in metabolic diseases 5.1 PKU PKU, a quintessential inborn error of metabolism, primarily stems from pathogenic variants in the hepatic PAH gene

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The approach emphasizes the codependent and continuous application of healthy dietary patterns and regular engagement in PA, sports, and exercise, which serves to address the dynamic interplay between energy intake and expenditure (163, 238)

Exp Neurol 288:104113 Li L, Xu J, Wu M, Hu JM (2018) Protective role of microRNA-221 in Parkinsons disease