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To evaluate the potential utility of the described dimeric macrocycles in the repair of damaged cells and in organ tissue regeneration, we next examined whether these compounds were able to elicit phenotypic changes in cells

Compared to non-supplemented individuals, the supplemented individuals had reduced DNA strand breaks in lymphocytes exposed to free radicals in a test tube assay (53)

Although the SPH domain alone cannot activate c-MET, mutations that disrupting the interaction between HGF-SPH and c-MET-SEMA significantly reduce HGF-induced c-MET activation, validating the functional importance of this interaction 15

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