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Post-translational modifications of EAAT1 and EAAT2 include palmitoylation, sumoylation, s-nitrosylation, and ubiquitination.[ref] Palmitoylation is a modification that adds a fatty acid called palmitate to the glutamate transported so that it can be anchored in the cell membrane of the astrocyte

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The original approved version was discontinued in 2008 for commercial reasons, not safety concerns

FIGURE 9 3.2.7 The selenocysteine adventure The development of the previously mentioned tRNA Sec UTu represents a significant achievement as it allows SECIS-independent selenocysteine incorporation at the amber codon ( Sec UTu by designing a new tRNA, tRNA Sec UTuX (Miller et al., 2015) based on the co-crystal structure of Aquifex aeolicus SelA and Thermus tengcongenisis tRNA Sec ( Sec UTuX not only enhanced SelA-mediated conversion compared to the original tRNA Sec UTu but also improved serine charging efficiency by SerRS, resulting in an increase in the yield of selenoprotein synthesis