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Although there were only marginal increases in intracellular GSSG levels ( P = 0.064), IL-13 increased extracellular (apical supernatant) GSSG ( P = 0.009), while lowering both GSH ( P = 0.012) and GSH:GSSG ( P = 0.006

Urinary 8-isoprostane as a biomarker for oxidative stress

et al., 2018a)

This review introduced the basic information of BBB structure and physiology and discussed the different strategies to enhance BBB crossing in detail as well as the bypassing routes and mechanisms