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Although the primary function of mitochondria is to generate ATP as an energy molecule required for countless cell functions, a small fraction of electrons from the ETC are transferred directly to O 2 , resulting in the generation of the superoxide anion, which can give rise to other ROS as well as reactive nitrogen species (RNS)

Li Y, Zhu S, Luo J, Tong Y, Zheng Y, Ji L, et al

Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via Sirt1-mediated deacetylation of p53