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Given the beneficial effects of several precursors and inhibitors summarized above, these strategies may be promising for finding a therapeutic strategy for AD, either as lead molecules or in combination approaches with other classes of molecules or drugs, with several studies having been launched at the clinical level

At the molecular level, copper directly interacts with A and tau proteins, facilitating their abnormal aggregation, enhancing neurotoxicity, and promoting both A deposition and tau hyperphosphorylation, ultimately leading to neuronal dysfunction and injury (185)

IFN- 1b plus atorvastatin has been shown in some studies to significantly lower high-sensitivity C-reactive protein levels in patients, indicating an anti-inflammatory effect of atorvastatin in MS (281)

Garcia ES, Sandwell DT, Smith WH (2014) Retracking Cryosat-2, Envisat and Jason-1 radar altimetry waveforms for improved gravity field recovery