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GSSG generated in these processes can be either recycled to GSH by a NADPH-dependent reaction, catalyzed by GR 3 , or pumped out of the cell by ATP-dependent processes, with multidrug resistance-associated protein-1 (MRP-1) being the major pathway for GSSG efflux 33

Int J Mol Sci 19(10):3394 Koss DJ, Jones G, Cranston A, Gardner H, Kanaan NM, Platt B (2016) Soluble pre-fibrillar tau and -amyloid species emerge in early human Alzheimers disease and track disease progression and cognitive decline