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Lactobacillus species, in particular, are among the most widely used probiotics, and their depletion is associated with IBD progression [40, 41]

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A third site, Site 3, at the bottom of the figure also sampled frequent contact with linoleic acid, but was not tested as a candidate for mutation given the sites proximity to the binding interface with the -subunit, reduced contact times compared to Sites 1 and 2, and the diffuse nature of the interaction surface