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These observations are usually mild and manageable in research settings but they highlight the importance of monitoring and adjusting research protocols as needed

To validate these findings, future work should focus on randomized controlled trials testing integrated lifestyle interventions using functional foods and exercise, with endpoints such as recurrence, inflammation, and quality of life and personalized, omics-guided strategies to match specific dietary and physical activity regimens to individual epigenetic or metabolic profiles

SD, RD, and ZS are employees of Lonza, while KJ is a consultant to Lonza

PloS one 8 , e76339 (2013)