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Moll van Charante EP, Richard E, Eurelings LS, van Dalen JW, Ligthart SA, van Bussel EF, Hoevenaar-Blom MP, Vermeulen M, van Gool WA

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The compromised barrier allows for the translocation of luminal microbial components, which, along with damage signals from dying cells, activates inflammatory pathways This triggers a positive feedback loop involving oxidative stress, lipid peroxidation, the release of pro-inflammatory cytokines, and the activation of matrix-degrading enzymes with concomitant downregulation of junction proteins that permit microbial invasion

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