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generadas por la nicotina y el benzopireno presentes en el humo del tabaco que incrementan la produccin de melanina ( 29 , 31 , 32 )

In a multinational double-blind trial (EORTC 18071 [NCT00636168]), patients with stage III melanoma, who had complete resection, were randomly assigned (1:1) to receive either ipilimumab or placebo.[30][Level of evidence B1] Exclusion criteria comprised patients with lymph node metastasis larger than 1 mm, in-transit metastasis, resection occurring more than 12 weeks before randomization, autoimmune disease, previous or concurrent immunosuppressive therapy, previous systemic therapy for melanoma, and an ECOG PS score higher than 1

doi: Compliance Statement This product is intended for laboratory research use only and is not approved for human or veterinary use