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However, study reported that the one-year clinical remission rate is only around 40%

These alterations result from generation of highly reactive free radicals leading to peroxidation of membrane phospolypids rich in polyunsaturated fatty acids, particularly in conditions with increased intracellular iron and decreased antioxidant systems (namely glutathione) ( Iron plays a crucial role in the synthesis of neurotransmitters in the brain such as DA, epinephrine, norepinephrine and serotonine, and in the production of ATP in the mitochondria through the process of electron transport in an organ like the brain that requires a considerable amount of energy

doi: 10.1016/j.tjnut.2023.05.012 23 MathewsDMJohnsonNPSimRGOSullivanSPeartJMHofmanPL

Comparison of oral iron chelators in the management of transfusion-dependent beta-thalassemia major based on serum ferritin and liver enzymes