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The collagen-dense tumors were additionally characterized by an increased expression of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2)

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Details of the effect of NO on smooth muscle and the heart will be discussed elsewhere in the curriculum

Flavin-mediated reduction of a protein disulfide bond Flavin-mediated oxidation of a protein disulfide bond As was stated earlier, a high intracellular concentration of reduced glutathione (GSH) serves to maintain proteins in the free thiol (reduced) state