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(3) Despite being non-significant here, we suggest plasma samples be deproteinized prior to storage, as spontaneous oxidation of free GSH to GSSG may occur if samples are stored for long periods of time

site of OXPHOS: inner mitochondrial membrane)

In this review, our analysis concentrates primarily on the UA-induced activation of immune cells, the consequent cytokine expression, and detrimental inflammatory responses arising from the imbalance in the immune cell populations that contribute to the progression of HUA and its comorbidities

More severe symptoms requiring immediate emergency care include jaundice (yellowing of skin and eyes), dark urine that looks like tea or cola, pale or clay-colored stools, severe abdominal pain, and extreme confusion or difficulty staying awake