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Studies in mice lacking PPAR/ indicated its roles in regulating hepatic FAO and antiinflammatory responses in Kupffer cells (369, 370)

202,203 In vivo, astrocytes are more sensitive to periods of ischaemia, although they still tolerate them better than neurones

In MASLD, the metabolic environmentmarked by hepatic steatosis, increased ROS generation, and, in some cases, iron accumulationcreates a permissive context for ferroptotic processes to be initiated and sustained [125, 126]

An antioxidant is, almost by definition, a molecule that readily reacts, and both reduced glutathione and ascorbic acid oxidize on contact with light and air, converting to forms that no longer behave the same way