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Also, CYP is detoxified by glutathione conjugation leading to a reduction in GSH levels and the concomitant rise in oxidized glutathione levels (Abdul-Hamid et al

Two types of desensitization, homologous and heterologous, were described

Among oral treatments, methotrexate is the most strongly associated with hepatotoxicity, with long-term use linked to hepatic fibrosis and cirrhosis

Furthermore, an overproduction of lipases along with the previously reported enhanced -oxidation (Patil and Jain, 2019) together indicates that the stored lipids are used for energy production (Figure 9)