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Among the chemical classes/pathways detected in the DCM group based on diet type but not in the DCM versus healthy control group were those related to polyunsaturated fatty acids (e.g., alpha linolenic and linoleic acid, omega-3 and omega-6 fatty acids), regulation of lipid metabolism by peroxisome proliferator-activated receptor-alpha, multiple G protein-coupled receptors, and mitochondrial biogenesis

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Impaired NOS activity is closely associated with insulin resistance (Kashyap et al., 2003)

The characteristic neuropathology includes cerebral edema, atrophy, white matter abnormalities, and ventricular enlargement, progressing to seizures, coma, and cognitive impairment-clinical manifestations consistently exacerbated by concurrent acidosis or systemic inflammation (Longo et al