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Remarkably, the most significant aspect is the substantial enhancement of immune responses triggered by electroporation, which can be as much as 100 times greater than that achieved with traditional injection methods (van Drunen Littel-van den Hurk and Hannaman, 2010)

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Clinically validated LNPssuch as those used in SARS-CoV-2 mRNA vaccinesare composed of ionizable lipids, cholesterol, helper phospholipids, and polyethylene glycol (PEG)-lipid conjugates, which together facilitate endosomal escape, structural stability, and reduced immunogenicity