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Thus, APE showed significant cytotoxicity toward both PBMCs and PMNs compared to the control group, with PBMCs being more sensitive to APE (Fig

(3) Additional use: Pyridostigmine is also used as prophylaxis against organophosphate nerve agents (e.g., soman) in military settings

doi: 10.1002/acn3.580 107 HancockDBMartinERStajichJMJewettRStacyMAScottBLet al

149 Under specific conditions, ROS can bypass these pathways to induce pyroptosis, driven by inflammasome activation (e.g., NLRP3) in response to PAMPs/DAMPs, the predominance of inflammatory caspases (caspase-1/4/5/11) over caspase-8 or RIPK3, and cell-specific mechanisms prioritizing cytokine release (IL-1/IL-18) in immune cells like macrophages