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Redox Signal 8 , 753762 (2006)

Caspase Activity Assays Probes for Measuring Caspase Activity Caspases (cysteine-aspartic proteases or cysteine-dependent aspartate directed proteases) are a family of protease enzymes whose functions are intimately linked with the processes of apoptosis (programmed cell death), necrosis, and pyroptosis (inflammation)

This strategy suffers from various drawbacks such as long reaction times (up to several days), low yields or lack of success in many targets, probably due to the accumulation of kinetically trapped folded intermediate (dead-ends) (Fig

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