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These shifts are acceptable when benefits in efficacy or tolerability are clear, but they underscore the need for systematic characterization because nanonisation should not be assumed to be inherently safer

As observed in cancer cells, injecting this inducer caused an escalation in intracellular iron levels, accompanied by ROS production and GSH depletion, ultimately triggering ferroptosis [134]

[23] showed that pigs pretreated with chemically modified tetracycline 3 (CMT-3) 12 h prior to intravenous LPS developed less lung injury, less edema and hypoxia by inhibiting MMP-9 and MMP-2