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Table 4 Representative clinical studies evaluating tumor heterogeneity using multi-region tissue sampling, liquid biopsy, and multimodal imaging approaches

doi: 10.1001/jamadermatol.2021.1688 2 XuZChenDHuYJiangKHuangHDuYet al

Oxidative stress, in turn, causes modifications in lens proteins (including enzymes, crystallins and other chaperones), thereby reducing their solubility and stability, and ultimately promoting crystallin aggregation (11)