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While sufficient amounts are often obtained through diet alone, some conditions prevent the body from using Vitamin B12 to ensure their body functions normally, especially in older adults and You may need Vitamin B12 supplements if you have poor nutrition, HIV, cancer, pregnancy, celiac disease, alcoholism, stomach problems, age and vegan diets that restrict animal products and rely on plant foods

Specific Adverse Effects Reported in Clinical Trials While the overall safety profile was excellent, clinical trials documented all adverse events regardless of severity or causality

Seo J, Pao P-C, Kritskiy O, et al (2020) A cyclin-dependent kinase 5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

Overview: How is alcohol metabolized by the body