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doi: 10.3389/fnut.2021.759507 Received 16 August 2021 Accepted 18 October 2021 Published 25 November 2021 Volume 8 - 2021 Edited by Xian Wu, Miami University, United States Reviewed by Maria Elisa Drago-Serrano, Universidad Autnoma Metropolitana Unidad Xochimilco, Mexico

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Although peripheral 5-HT cannot cross the BBB directly, it influences CNS function indirectly by activating vagal afferent fibers, modulating immune cells, and affecting tryptophan availability ( 4.1.2 The GABA pathway Beyond the 5-HT system, GABA, as the most abundant inhibitory neurotransmitter in the CNS, has a core role in mood regulation and anxiety control