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Because at the achieved plasma insulin concentration the hepatic glucose production should be suppressed, the amount of glucose required to maintain steady-state euglycemia was assumed to be equal to the total-body glucose disposal

In the nucleus, receptor dimers bind to androgen response elements (AREs) in the promoter regions of target genes, such as prostate-specific antigen (PSA) and transmembrane protease serine 2 (TMPRSS2), etc , to which they recruit various coregulatory proteins to facilitate transcription, leading to responses such as growth and survival 7,8,9,10,11,12

doi: 10.1371/journal.pone.0100627 46

The DSM-5, ICSD-3, and ICD-11 recognise this by allowing co-morbidity outright