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Methods and materials Cell line generation and genotyping Whole blood samples from plain regions were obtained from the Taizhou Institute of Health Sciences, Fudan University, while samples from high-altitude regions were collected from healthy Tibetan individuals in Lhasa, Xizang

To determine whether the ASXLs binding mechanism is conserved in BRD4 ET , we tested ASXL2 EBM (aa 615-628 of ASXL2) and ASXL3 EBM (aa 10081021 of ASXL3) peptides in 1 H, 15 N HSQC titration experiments and fluorescence spectroscopy (Fig