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168 Cadmium exposure leads to gut flora dysbiosis, reduced fecal BSH activity, and elevated intestinal tauro--muricholic acid levels in mice, subsequently inhibiting the intestinal FXR/FGF-15 signaling pathway, promoting hepatic bile acid synthesis, and ultimately triggering bile duct proliferation, inflammation, and injury

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While some users report enhanced local effects, the evidence for superiority over subcutaneous administration remains unclear, and complications including nerve irritation present greater concern

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