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In EAE, TNFR1(p55) is supposed to be responsible for the detrimental effects of TNF- by initiating and exacerbating the course of disease while immunosuppressive and immunoregulatory properties of TNF- are thought to be mediated by action through TNFR2(p75) (Eugster et al., 1999

However, the efficacy of nasal administration may differ compared to other methods, and individual responses may vary

These medications work by depressing the central nervous system, producing a calming effect

Molecular diagnosis of hereditary spherocytosis by multi-gene target sequencing in Korea: matching with osmotic fragility test and presence of spherocyte