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These results are consistent with previous reports 49 , UVB irradiation induced increased expression of pro-apoptotic proteins Bax and caspase-3 in concert with the repression of antiapoptotic proteins Bcl-2, while accompanied by collagen loss and an increase of MMPs

The same exosomes also remodel the microbiota-metabolite network, upregulate FXR expression, restore barrier integrity, and reduce colitis inflammation [478], thus linking immune suppression with microecological repair into a closed-loop

It is also abnormally low in ME/CFS patients (308, 309)

Interestingly, either YTHDF1 silencing or ALKBH5 expression restoration partially reversed ferroptosis