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Patients with gastrointestinal diseases, like gastric ulcers, leaky gut, irritable bowel syndrome, and Crohns disease

Some neonatal studies show no depletion at therapeutic doses, suggesting babies may metabolize it differently

Specifically, MG modifies the transcriptional coactivator p300 and reduces its ability to bind to HIF-1, thus limiting the function of HIF-1 to promote angiogenesis under hypoxic conditions and inhibiting nutrient supply to the tumor (118)

These are creams or gels that you probably used prior to starting isotretinoin therapy and these medications are related to isotretinoin and have some similar effects