US20200102274A1 - Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof - Google Patents Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof Download PDF Info Publication number US20200102274A1 US20200102274A1 US16/499,228 US201816499228A US2020102274A1 US 20200102274 A1 US20200102274 A1 US 20200102274A1 US 201816499228 A US201816499228 A US 201816499228A US 2020102274 A1 US2020102274 A1 US 2020102274A1 Authority US United States Prior art keywords nnmt cations amino cation adipocytes Prior art date Legal status (The legal status is an assumption and is not a legal conclusion
It is recommended that metformin treatment should continue while the B12 deficiency is corrected, in view of the drugs known benefits in type 2 diabetes and its central role in treatment guidelines.
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Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)
