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These results remain heterogeneous depending on cellular models and concentrations used, which probably reflects the peptide's pleiotropic complexity rather than a single linear mechanism

Brigelius-Flohe R, Aumann K-D, Blcker H, Gross G, Kiess M, Klppel KD et al (1994) Phospholipid-hydroperoxide glutathione peroxidase

588,589 -syn is functionally associated with iron, calcium, and lipid metabolism, and its aggregation has been found to induce ferroptosis by interacting with cellular membrane and accelerating lipid peroxidation