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Free Rad Biol Med 2002

The discontinuation rate in clinical trials ranged between 20% and 50% within the first year, with GI intolerance being the primary reason

The significant loss of DC subset upon GW1929 treatment was that of cDCs (CD11c + CD45RA - ), including CD8 + DCs (CD11b low CD24 high ) and CD8 - DCs (CD11b high CD24 low/- ), but not pDCs (CD11c + CD45RA + ) ( Supplementary Figure 3A