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Because of their relative concentrations, a small fractional conversion of ATP to AMP in the RBC yields a large relative increase in AMP concentration, which activates PFK-1

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Figure 5 T2DM is a multifactorial metabolic disease characterized by chronic hyperglycemia and dyslipidemia, which can induce long-term low-grade inflammation and oxidative stress, ultimately leading to extensive damage to target organs ( Insulin resistance in T2DM often progresses from prediabetes and impairs pancreatic buffering activity during hyperglycemia, and this insulin resistance can extend to the brain ( In conclusion, there is a strong association between the pathophysiological mechanisms of T2DM and cognitive dysfunction