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While more human research is needed, current user feedback and practitioner insights suggest the following best practices: Standard Dosage Most users take 50100 mg per day , typically in divided doses (e.g., 2550 mg twice daily) to maintain stable blood levels

More than a year later, in September 2013, the regulator rejected the application, asking the company to perform another well-controlled randomized trial to better determine the safety and efficacy of the investigational product

For a deeper medical perspective, you can read A review of lumbar radiculopathy

In my experience this is corrected with a few days calcium supplementation, and is the beginnings of hypo calciemia