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Adolescents exhibit the most favorable prognosis, with 40%50% achieving complete stable remission and an additional 30%40% maintaining excellent functional status (91)

Also, of importance are the interactions of these receptors with cancer directly or through the TME, which may also be impacted by oncogene expression

Another study conducted on 50 patients who followed a discontinuous therapy with statin and supplemented with 240 mg/day CoQ 10 for 22 months, showed that the incidence of fatigue decreased from 84%, observed at the beginning of the treatment, to 16% at the end of the study [45]

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