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JCI Insight 1 , e85904 (2016)

Therefore, it is under significant clinical consideration (182)

The age-related decline in the GSH content in both male and female mice was also associated with a decrease in the amounts of glutamate cysteine ligase (GCL) mRNAs and proteins as we have reported previously in male rats, further suggesting an important role of GCL in maintaining GSH homeostasis during the aging process

Currently, life-threatening acute liver failure, cannot be drug-treated, leaving liver transplantation with potential bridging plasmapheresis as ultimate option for rescue from death