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Glutathione functions as a key regulator of redox homeostasis, directly neutralizing reactive oxygen species and free radicals, thereby protecting cells from oxidative damage

Loss of neuronal GSH has also been linked to microglial activation and complement-mediated neurodegeneration, further emphasizing the link between redox imbalance and immune dysregulation (Hashimoto et al., 2023)

Studies have shown that taking phytoceramides orally can help reduce the appearance of wrinkles and age spots

Microglial NF-B activation under GSH-depleted conditions creates a pro-inflammatory loop where increased ROS promotes NF-B activation, which upregulates inflammatory cytokines and further stimulates oxidative stress (Liu et al., 2017