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Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins

As examples, SKOV3 (IC 50 = 0.990.08) and HepG2 (IC 50 =0.870.07) have shown almost the same level of sensitivity, however, after the exposure to cisplatin the GSH level was increased dramatically (about 2.5 times), but decreased significantly (about 2 times) in these cell lines, respectively

Holvoet P, Laroche Y, Lijnen HR, Van Hoef B, Brouwers E, De Cock F, Lauwereys M, Gansemans Y, Collen D: Biochemical characterization of single-chain chimeric plasminogen activators consisting of a single-chain Fv fragment of a fibrin-specific antibody and single-chain urokinase