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[#1] diagnostic clue: refractory hypoxemia Methemoglobinemia typically causes the pulse oximeter to report a saturation of ~82-86% (even if the PaO2 is very high)

NAD+ provides the energy required for these detoxification processes to function efficiently

A promising phase I clinical trial using cotreatment of trientine (a copper chelator) and carboplatin has shown CTR1-mediated higher cisplatin uptake and better outcomes [329, 330]

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